New Breast Cancer Study – Non-Toxic!
Lemon Essential Oil Has Shown Chemopreventive And Chemotherapeutic Activity With Breast Cancer!
“We conclude that limonene distributed extensively to human breast tissue and reduced breast tumor cyclin D1 expression that may lead to cell-cycle arrest and reduced cell proliferation.”
Prev Res (Phila). 2013 Jun;6 Human breast tissue disposition and bioactivity of limonene in women with early-stage breast cancer. Miller JA1, Lang JE, Ley M, Nagle R, Hsu CH, Thompson PA, Cordova C, Waer A, Chow HH. Author information Abstract Limonene is a bioactive food component found in citrus peel oil that has shown chemopreventive and chemotherapeutic activities in preclinical studies.
We conducted an open-label pilot clinical study to determine the human breast tissue disposition of limonene and its associated bioactivity. We recruited 43 women with newly diagnosed operable breast cancer electing to undergo surgical excision to take 2 grams of limonene daily for two to six weeks before surgery.
Blood and breast tissue were collected to determine drug/metabolite concentrations and limonene-induced changes in systemic and tissue biomarkers of breast cancer risk or carcinogenesis. Limonene was found to preferentially concentrate in the breast tissue, reaching high tissue concentration (mean = 41.3 μg/g tissue), whereas the major active circulating metabolite, perillic acid, did not concentrate in the breast tissue.
Limonene intervention resulted in a 22% reduction in cyclin D1 expression (P = 0.002) in tumor tissue but minimal changes in tissue Ki67 and cleaved caspase-3 expression. No significant changes in serum leptin, adiponectin, TGF-β1, insulin-like growth factor binding protein-3 (IGFBP-3), and interleukin-6 (IL-6) levels were observed following limonene intervention. There was a small but statistically significant postintervention increase in insulin-like growth factor I (IGF-I) levels.
We conclude that limonene distributed extensively to human breast tissue and reduced breast tumor cyclin D1 expression that may lead to cell-cycle arrest and reduced cell proliferation. Furthermore, placebo-controlled clinical trials and translational research are warranted to establish limonene’s role for breast cancer prevention or treatment. PMID: 23554130
Your Friend In Health, Michelle with www.ihelpbackpain.com
If you would like my support with placing your first Young Living Oil order I am here to make the process easy for you. Call me at 407-628-2176 or e-mail me: firstname.lastname@example.org – My Young Living Member Number is 842773.
As a distributor you will enjoy 24% off all your oils, plus you will receive “free” product and reward points to earn more “free” products. Most importantly you will have a great essential oil coach and the purest and most potent essential oils available today. Allow me to help you on your Young Living Essential Oil Journey.